After Moving Computer and Hooking Devices Back Up, Track Inputs Default to Multiple Device

As the title suggests, I have saved projects that work fine as long as I don't move my computer.  When I take everything apart and move it to another studio or to a gig, reconnect the cables to where they were before (all USB cables to the port they came out of), I play and nothing works.  I go into the track inspector, and the inputs have defaulted to something else and I have to manually set every one back to where they should be. What gives here?