Audio Looping Issue

Hi All,
 
This is a bit of a strange one. I've simplified to the point where I have a project with one audio track, which has a wav file of a drum part on it which covers around 60 bars. I set a loop points on bars 5-6, and start the track playing. The drum file plays fine, and loops on bars 5-6 as expected. If i then click the Loop On/Off button to remove the loop points, the track then advances past bar 6, but the audio gets messed up - I get output for a few seconds, then it goes quiet, then plays for a few seconds, goes quiet etc etc, for the rest of the 55 bars.
 
I've tried this on 2 different computers, with two different audio interfaces, and with the internal sound card using WASAPI - all with the same result.
 
Seems a pretty trivial thing, but the fact it happens on two different setups makes me think it's a 'feature' - although quite an annoying one!
 
Thanks in advance for any insight.
 
PS Currently using SPLAT 2017.01

Thanks brundlefly, that seems to have done the trick
 
Enabling 'Set Now Time with full reset' causes a pause in audio playback when toggling the loop region, so wasn't what I was after.
 
Changing the playback I/O buffer size looks like it resolves the issue. I had it set at 512KB; moving it up to 1024 made no improvement, I knocked it down to 256 and the audio after the end of the loop point plays back correctly after toggling the loop mode to off.
 
Bit counter-intuitive that reducing the buffer size will improve playback performance, but glad to get it resolved. I don't know enough about it really, but it does smell a bit like a 'feature' -  audio playback getting corrupted after removing loop points, when it plays back fine if not looped, doesn't seem quite right.
 
Have also managed to convince myself that this didn't happen previously -  I might try rolling back a few versions and see if I get the same issue when I have time. Then again, I can convince myself of most things given enough slack... 
 
Thanks again for the help.