Hi Twigman:
RME audio interfaces are known to be good interfaces capable of running with stable low latency settings. I don't have one but there are a number of regular forum members who do, and they may chime in here sooner or later.
To eliminate the problem being a device driver, on Yahoo or Google, search the DPC Latency Checker and download it. Run it to see if you get any readings that spike into the red areas of the chart. If you do, there is a device driver not behaving good.
By disabling devices in Device Manager one by one, you can troubleshoot to see which device driver may be the culprit.
Make sure the main system drivers for your system are up to date, such as motherboard, audio interface, and graphics card. Also check to see if there is a BIOS update for the motherboard which you can try.
Some things that may be contributing to the problem are:
-Wireless network adapters
-Enabled Power Management features in the BIOS
-An untweaked operating system
-Adjusting the playback and record buffer sizes in Options\Audio Advanced tab
Hope this helps.
post edited by thomasabarnes - 2010/07/21 10:29:04