Sound glitches when dragging patterns while playing

Are you talking about moving MIDI notes in the Piano Roll while audio is playing? If so, increasing the preference for MIDI playback ("prepare using X millisecond buffers") can make it better, or less glitchy. I went from 250ms to 500ms, and it is better.
 

25,563µs (microseconds) max latency? Ouch. Yes, that will cause a problem. Overall latencies should be kept as low as possible, perhaps below 500µs.
 
I would see if uninstalling the graphics card drivers and reinstalling the newest set will help. DirectX is causing a huge lag. Nothing really can be done in Sonar preferences except for accessing your ASIO control panel to increase the buffer size in an attempt to counteract your system latencies.
 
Are you also experiencing a lot of audio dropouts and Sonar audio-engine stops? If so, then we need to get to the root of the problem, stat!  If not, then perhaps you're willing to compromise and look beyond the glitchy-ness while editing so as long as the rest of the audio, production and rendering process is good to go.
 
Prior to my current hardware configuration, I had a Gigabyte mobo that was the absolute root cause of some HUGE latencies internal to my system. Other forums reported the same thing, though sparsely. I ended up getting a different mobo (an Asus), and my system latencies are very low.

Usbport DPC problems sounds like something connected to USB is spiking while you are dragging. Could it be some settings in the gaming mouse?

Still checking the issue...I've seen that the cpu rises at 40% usage when moving the mouse, but only in sonar...Weirdddddd!!!!!

Doubt if a PCI USB card will change the interrupt structure that leads to those DPCs, except make it worse. I'm wondering if there is some way to go into the mouse configuration settings ("properties" associated with the driver you installed with the mouse) to make it less aggressive in sampling the mouse position or generating interrupts when the mouse moves.

Send a problem report. I am going to do the same.

Bringing this one back to see if anything has improved...
 
I submitted my problem report, and Cakewalk is asking for me to call their tech support number. With them being on the east coast, and the hours of my work, it is difficult to get a chance to call.  Cakewalk says it's a setting or configuration issue.
 
On a side-yet-related note, I have my PCIe Firewire card installed, and it did not help at all. Despite being a TI chipset, it has offered no increased performance or the ability to obtain smaller ASIO latencies.  The buffer size seems best at 96 (set via MixControl, and roundtrip is 7.9ms.  No matter if running on the PCIe card or the motherboard's Firewire port, these settings offer the cleanest and most-stable performance. I guess the LSI chipset on the Asus P5Q is fairly compatible with the Focusrites.
 
Iceaddiction, have you made any progress?