The only thing I might suggest, if you want to be ultra-careful, is to move any software licenses you have installed on your DAW back to the cloud (in other words, deauthorize your apps and plugins). That way, if something untoward happens during the upgrade, you won't have to deal with getting your licenses back from the vendors (or their third party, which is usually worse).
From my upgrade, the only real problems I had were: 1) getting a stable graphics card driver, and 2) (and I knew this going in) getting a Win10 driver for my Tascam audio i/f (that took about 30 days post Win10 birthdate).
My only real issue remaining is waiting on AMD to clean up the Radeon HD x64 driver for Win10. [Edit 2: Changed my mind. I ordered a Gigabyte GV-N75TWF2OC-4GI (nVidia GeForce GTX 750 Ti Windforce 4 GB) yesterday. Should be here tomorrow.]
Edit 1: If you have any Arturia VSTs authorized via their ASC (Arturia Service Center), be aware that I have yet to get ASC to run on my PC under Win10. It installs OK, but immediately aborts to the OS when I try to run it. Arturia support have been no help, so I'm going to open a new ticket, and try again.
post edited by TheMaartian - 2016/03/09 08:54:26