Region FX Artifacts

Every once in a while when I am using a "region fx" (usually Melodyne (I have 'Studio') but, sometimes using 'drum replacer') ...I believe after the rendering process...I get about a second of pure distortion that has been actually recorded onto a separate track ...if audio was recorded on that section of track the audio is destroyed ...replaced with that "second of static" ...when I hit play it is a "soft" distortion...like "fffiiiit" ...sadly if I don't catch it and hit undue I can lose a very valuable (un-replaceable) section of audio (I have Sonar Platinum)...I have a jpg image I created to show you what I see: