Guitar Rig 5 Buzzing

Whenever I use Guitar Rig 5, I always hear this faint buzzing in the background which becomes more severe when the gain is turned up. I don't think it is the settings of the interface because the buzz is almost unnoticable when I am not using guitar rig but I could be wrong.
I am using a Focusrite Saffire 6 USB. I would post settings but I am unsure what ones are relevant or irrelevant.

Cheers

Yep. You need to fiddle with the gate button. Just like a real amp the more distortion/effects you put on the signal the more hum/feedback/general noise you get. There is a feature where you turn your guitar and interface up to recording level but don't play anything (dampen the strings with your hands) then when you are sure it's at the quietest your signal will be you merely click the Gate knob and it auto adjusts to cut out all the noise. This way it just BARELY applies the gate up to the point it is need but as soon as you play the gate opens up. This however used to work quite well for me but for some reason stopped so I just adjust the knob the old fashioned way. Just get the signal to it's most idle at levels you want to record at then adjust the knob until the hum and noise just barely disappears.

I have the same probleme i have 2 humbuckers and when i record my sound to high or to low wnen a finish project

Does the buzzing go away when you touch your strings?

Many of the high gain presets for Guitar Rig are noisy at low signal.
There is a Noise Gate rotary knob up at the top of the interface that you can adjust to get rid of that noise.
Most of the cleaner presets should not be noisy. Might be as simple as the software mimicking what an analogue fx chain would do.

I have alot of issues with single coil pickups especially seated so close to my computer monitors. Step away 5 feet no noise, tilt the guitar away from the monitor, no noise.