Hi - I would suggest you check any antivirus software that may be running when you are in a Sonar/Cakewalk session. One of the normal defaults for many/most antivirus software programs is to check every file that gets opened, such as all of your sample files. This adds to the work your computer has to do.
What I do, and a lot of folks do, is to go into the antivirus software settings, and look for whatever settings allow you to exclude certain file paths or even individual files, from getting scanned. Since your sample libraries were all scanned when you downloaded or installed them, and they are static, you can safely exclude them from antiviral scanning. The exclusion process is also called White Listing.
I suspect you have performance issues with your sample libraries - possibly caused or aggravated by the antivirus program, and/or also occurring due to disk location of the sample libraries.
If synth plugins, that are not sample-based, are not exhibiting these sound problems you call parasites, then it seems to me to be most likely to be something interfering with the streaming of those sample libraries. SO, what happens with NON sample-based plugins, such as Pentagon I, Z3TA+2, Triangle II, Square I, or any other such non sample-based plugin you may have? (There are scads of freeware synth plugins out there - check for 64-bit versions). If you do NOT experience these issues when playing a synth that doesn't rely on loading and streaming sample-based sounds, then clearly there is something interfering with processing your sampled sounds.
Also, please go into the Cakewalk settings, and look under the Audio section > Playback and Recording, and please list the Driver Mode, and also look under the Audio section> Devices, and list what specific Input Driver and Output Driver is checked. I want to make sure you are using ASIO drivers for your actual audio interface, and not accidentally using something like ASIO4ALL.
I hope you see this and respond.
Bob Bone