What kind of music are you producing?
Surely something that lends itself to the use of TR-8 sounds? I guess if you're going for an old-school They Might Be Giants, alt-rock-meets-garage-indie-childrens-band sound, it'd work, but (obviously) the style of music and what you're hearing in your head would determine what work best.
IMOX (my new acronym for "in my own experience", use it or lose it! :D ), if I can HEAR it in the mix, then usually the basic, out-of-the-box settings and sounds that apply to what I'm adding function well as a placeholder until I get something concrete that mirrors EXACTLY what's in my head. Otherwise, when throwing things at the wall to see what sticks, sometimes it pays to just try different samples or take it back to the drawing board.
just IMOX, of course