Which strongly suggests it's your interface > monitoring.
Check your interface and monitors for loose connections - sometimes rebooting can sort of "bridge" a slightly loose connection - it happens with the surround sound on my cinema system all the time. Jack the volume up or switch it on/off and the sound in the rear speakers comes back.
Check your USB cable - swap it out if possible with a known to work, good quality one.
Also see if there's any setting on your interface or the driver software which might be contributing.