I run at 24/48k and have NEVER run into performance issues on either a system with an i7 2600k OR a system with an AMD A10 7850 (Both with 32 GB of memory).
I also have one SSD for Windows (Win 10) and all applications, and multiple 7,200 RPM HDD's splitting Cakewalk Projects, Native Instruments and Miscellaneous samples, and EastWest samples.
I run with CPU min/max both set to 100% and my cores are not parked.
Bob Bone