The 828x doesn't offer "PCIe via Thunderbolt"... so you won't see any performance gain by using it vs. the mkIII.
If you're after the lowest possible round-trip latency, go with the newer AVB series.
The Ultralite AVB is a very good audio interface... especially when you factor in cost.
The larger AVB units (1248, 8M, etc) offer specs that are slightly better than the RME UFX.
The best USB audio interfaces are great performers.
I leave my RME Fireface UFX on a 48-sample ASIO buffer size much of the time.
If you go with an audio interface that's a proven rock-solid performer...
The beauty is that you'll rarely give it a second thought.
It just works... without fail... without glitches... without hassle