I built my home and wired it all myself under the supervision of my buddy who is an electrician.
The trick is to be meticulous about the neutral at the panel and having lots of ground potential. It gets dry here in the summer and grounding can fade to nothing. I have 6 ground rods. We've been hit by lightning a few times and other than smelling melted plastic and ozone very little damage was done. My pump controller was blown off the wall and all the phone lines melted.
That was before we had a computer and since then I always unplug everything important during potential storms.
My friend knew I would be putting a studio in my attic so he recommended keeping any 110 V motor loads on one phase of the panel. Then we ran a special circuit to the attic on the other phase. Keeping fridges and freezers on the other phase. Nothing you can do about 240 Volt motors as they share both phases. This is only my pump and it's a long way from the house so it's not an issue.
The whole studio runs off this one circuit and directly to a Furman line conditioner. Turning off the furman shuts down the studio and I unplug it during storms.
I find guitar noise is directly related to the instrument it self. I have a lot of guitars. So if it's a noisy guitar orBass I upgrade the wiring and Pups.