I would say no as far as the ambient noise floor of the guitar pickups into a preamp section. The more you open the vol pot, the more the noise floor is exposed to the preamp (and is amplified) it does not disappear. If you are playing live at louder levels, once the preamp does it job, and passes the signal to the power amp section, the guitar noise is many dB below the amplified signal so it is not a problem at higher speaker volume levels. However, if you are recording your guitar direct into a DAW, the noise floor is more obvious due to the lower signal levels.
 
Oh yea, and if you have ground loops in the wiring of your guitar (or pedals) and unshielded control cavities then RF and hum may also be exposed to a preamp section (another can of worms). By the way, aluminum duck tape makes great Faraday cages to shield guitar cavities - one roll from Lowes will probably last a lifetime.

Take care,
h

I had a similar problem in my Yamaha hs80w's hs10w , after a lot of time I ended up cutting the earth on my Yamaha hs80s and the crackle and hum disappeared . Some say there is a fire hazard or electricution hazards involved with this ( so for my situation it's perfect because my monitors are in a dedicated room and only on when I am in there , been all good for over a year now !! )

I also disabled c-state in bios and something else which contributes to PC noise in speakers .

pinguinotuerto
Have you tried a higher end instrument cable with better shielding?

Apart from good wiring/shielding on the guitar itself, the cable cannot be overstated. I do a lot of solo acoustic work and will never use the stage cable, always using my own. All mine are D'addario/Planet Waves, or handmade with Mogami cable. I'm very particular with my tone and this is the first area of let down with cheap cable, plus loss of voltage/gain, which adds to hum/noise. The same applies in the studio when it's time to record, acoustic or electric. I've many noiseless and single coil strats and tele's, used for different sounds of course, but while noise can be a problem with single coil, it's part of the reason I will use it in the first place. Poor cable makes it impossible.
 
Everyone else has pretty much covered the earth loop thing for all the studio gear. It's all about attention to detail and checking all is well with house wiring. cheers. Dave.

sorry if I duplicate any tips, I didn't read every comment...
assume you take your electricity from a grounded box (here in Europe some kitchen electricity points are grounded usually).
that fixed 90% of hum here, the other hum was coming from a reading light I had on my desk.
a simple lamp/light can cause a lot of hum, or any other electrical device close to your music gear....or on the same electrical power chain...
 
good luck

Fluorescent lights are notorious for adding noise to electrical circuits.
 
Rocky

Seems the new LED lighting is quiet. I removed my old school florescent fixture and replaced it with a 4 socket light bar meant for a vanity ( bathroom) light. The kind that have 4 globe lights.  At first I had CFL's but now they are all LED light bulbs. Slowly my whole house is being changed over from CFL to LED as the CFL's die. CFL bulbs have a tiny ballast in them that is the source of RF noise. Not as bad as a full size Florecent with a big as ballast, but if they are close to you gear they are pesky. I like the light from the LED's better, they are warmer. 
LED's are also all I use for my live performance lighting. No more tripping breakers and hot fixtures. 

Hopefully you don't have any CRT displays. They induce noise into guitar pickups. Flat screens don't have that problem.

I've upgraded all my bulbs to LED and some of them generate a slight audible buzz. There are switching supplies in there. So beware. Oh, I like them because I could picked cooler light. Warmer/yellow light makes it harder for me to see as I get older.

z1812

I tried ferrite beads without success and am continuing to trouble shoot the problem. It happens with my Gibsons but not with my Fenders. I am told that is due to the noise cancellation on the Strat pick-ups.

I am hoping others will chime in with their experience.

All the best,
John

Provide the specifics on your GIbson.  Model and pickups.
 
As another poster pointed out, you narrowed the problem down to the guitar.  And Gibson's typically have humbuckers, which by nature are noise canceling.  Unless you have a P90 equiped (which is a single coil) Gibson.  

Brian Walton

z1812

I tried ferrite beads without success and am continuing to trouble shoot the problem. It happens with my Gibsons but not with my Fenders. I am told that is due to the noise cancellation on the Strat pick-ups.

I am hoping others will chime in with their experience.

All the best,
John

Provide the specifics on your GIbson.  Model and pickups.
 
As another poster pointed out, you narrowed the problem down to the guitar.  And Gibson's typically have humbuckers, which by nature are noise canceling.  Unless you have a P90 equiped (which is a single coil) Gibson.  

Thanks for your reply. The problem is with my Les Paul Traditional. It has Classic 57 hum bucking pickups. The interference changes depending on which way I face although the same facing does not always eliminate the hum. I tried a ground loop isolator between the Guitar and Amp but it didn't work.

Nice to see all the replies. Hopefully a good resource for people with similiar problems.