I am glad you found a solution for the clicks an that mouse issue, in that way.
I did have issues with such things back in the day of x3.
It seemed more so tied to HDMI audio device...than plug ins.
So, Just to be sure, when you setup up a music system for large inputs and outputs of audio, or reads and write, and audio playback.
It is best to reduce redundant devices, by disabling them.
So, in one of my tests, all "on board audio devices, and wi fi, and if need be Internet nics" get turned off through the bios
If you have two video cards, that have HDMI audio ...It can cause issues with the mouse , and your audio device being used, when using another audio source....too many Irqs used, and sharing occurs, some times at random boot up, windows will choose to share with audio ...more than one audio device...and you get issues.
So, it might not be the plug ins per say, or completely, although it seems to solve the problem, but a conjoined or confused servicing perhaps lies at the root...It just may be too much over servicing to root and route things properly between video audio, and another audio device, using what ever you are using for audio...And I do not think you are using HDMI audio for Sonar....eh?.
So try that out, and put back the th3 plug in and see if it continues to do so, if you want to try?...and see if it clears any....No harm in trying this out as it did solve my problems back in the day....Same thing was kind of going on...And some said to change my mouse..And that did not solve it...you can turn off hdmi through windows "control pannel/system devices...and or through the App for the video card i believe...
Hope it is cured though...with no relapses!
Cheers