I recently purchased a Focusrite Scarlett 6i6 New Generation USB Audio Interface. What settings can I apply in SONAR Platinum to achieve low latency? Currently the latency exceeds 25ms.
 
Thanks for any assistance.

One more question.  What is the recommended sample rate?

Try following the steps at the links below, and feel free to ask if you have more questions.
 
http://www.cakewalk.com/Support/Knowledge-Base/2007013376/Windows-Optimization-Guide
 
http://www.cakewalk.com/Support/Knowledge-Base/2007013182/Im-getting-a-delay-or-latency-when-recording-or-performing-synths

Using ASIO setting for my Focusrite always gave me high latency issues. Tried all sorts of adjustments to settings to no avail. On eventually reverting to WDM it made a huge difference - excellent latency, no juddering of display, CPU meter levels dropped.
 
(PS: Worked under the impression that ASIO was 'the way to go', and WDM was the "poor man's setting", older tech. But it solved the issues for me)

Thanks for your suggestions/recommendations!

Based on what others report, it seems that ~27 ms may be about as low as you can get with the Focusrite at 44.1 KHz. If your CPU can handle it, moving to a higher sample rate will also lower latency. I'd consider that a last resort, however, since you'll also be lowering the threshold at which the CPU runs out of steam on a large project.
 
Despite that limitation, I am a happy Focusrite user. That's because I just don't care about latency most of the time - the interface is capable of zero-latency monitoring when recording audio from outside sources such as vocals and guitars. Consequently, my buffers stay at 1024 all the time. The only exception is when I'm auditioning a new sample library and want to play it in real time with minimal latency, at which time I go down to 64 samples and run the sampler standalone.