zabs291
Thanks again to all for the advice -
Mike
Mike, just keep in mind the following, in case you have any further problems.
Win10, GeForce and USB.
Your system specs are very similar to my own. I gave up trying to get my Nvidia drivers to work with WIN10, SONAR, and USB devices, 2.0 or 3.0, now use onboard graphics only, and everything has been sweet since. The amount of people who have had similar problems to you, including your present interface, are enough for me to declare it's mostly a graphic's issue that relates directly to GT cards. It seems to come down to having exactly the right drivers, not necessarily the current ones, to get things harmonious, and it seems to change between what MB/CPU people have got. I only know I spent way too much time and paid way to much attention to issues on many forums, all coming down to one common thing, GT cards and the drivers.
I would suggest, unless you use your PC for other things, that you give serious consideration to removing and disabling all things GeForce, and see if your current interface begins to behave itself, if your happy with it otherwise. You certainly don't need dedicated graphics for SONAR with your current CPU as long as your MB supports your required monitor support. Most these days support 2 or 3.
I can highly recommend the Scarlett series too, and will be upgrading to the 2nd gen when it hits the shops. My next choice would be the Apollo.
I've since built a dedicated graphics/video editing PC with my GT card, which works brilliantly on it's own and with WIN10. Just wouldn't play with my interface or SONAR. Best of luck to you. Dave