The other important setup step is calibrating your speakers so that there is a consistent relationship between your audio interface output and perceived volume.
Bob Katz came up with what's called the K-system for doing just that. It's modeled on the way sound systems are set up in movie theaters. You will need an SPL meter to do it, but they're cheap and you can even download a free app for your smartphone that's not accurate but can get you into the ballpark.
Basically, the idea is to run white noise through your speakers at a specific dB level and adjust your volume control so that you're measuring 83dBSPL on each speaker or 86dBSPL on both. That way, you can correlate levels in your DAW to volume at your ears and be consistent when mixing. You don't need to mix at 86dB - that's too loud for most folks - but it's very important to mix at a consistent volume.