I had quite a few issues with Windows 10, but they are all related to my anti-virus programs. I'm not sure if this is why you might be experiencing issues, but if it might help, here's my tale:
I was originally using Kaspersky Anti-virus, which ran beautifully for me on Windows 7. But after upgrading Kaspersky (to the new Pure version) and Windows (from 7 to 10,) began a period of time where Sonar Platinum in particular became unusable. I had pretty much every glitch you could imagine encountering and more often than not, couldn't even get it to open without crashing. I didn't have the same trouble with other DAW's like FL and Studio One, but for some reason Sonar was held up or blocked almost every time I tried to run it.
I did a search and found that some people (not all) were experiencing a problem with Kaspersky, where it ignores user file and program exclusions and just blocks everything. I did a reinstall and even manually re-clicked the safety level exclusions, but still had major issues with Sonar. It culminated with not even being able to get google chrome to open, so in the end I got rid of Kaspersky and tried Bit Defender. It was better for most things, I could actually open Sonar but it would take a while to load up and I was still having trouble with stability.
I placed exclusions in Bit Defender for Sonar's folder and the Command Centre as well and then ran the Command Centre as Administrator to install the latest update. I ran Sonar as Administrator to open it up and for the first time in two months, it opened in seconds and there hasn't been a hitch since.
I was also finding my Quad Capture ASIO drivers would disappear from time to time, forcing me to restart. The fix was to place my Quad Capture file folder in the file exclusions as well. This was happening in other DAWs as well as Sonar, not something I ever had to bother with in Windows 7, but for some reason I had to now.
Note: I also found that placing file extension exclusions for loops, instruments, WAVs and NCW (native instruments sample files), made the start up of some of my samplers so much quicker. I was getting regular hang ups with large files, that would take forever to load and sometimes lead to a crash.
I'm not sure if this is the fix for you? But it might be something to look at before doing the whole unistall/reinstall schemozzle.