The Babyface's Hi-Z instrument input is 470KOhms according to the specs in the manual. Which is perhaps a little on the low side, 1MOhm or higher being generally considered a better match for the input impedance of a valve amp.
Having said that, 470KOhm is also the input buffer's impedance of a Tube Screamer and people generally don't complain about Tube Screamers affecting their tone for the worse when switched off. If you've any pedals that have buffers between guitar and interface the guitar will see that buffer in any case, not the Babyface's impedance. A good DI box with a 1MOhm+ input impedance might get you a bit more volume and treble, but so would any Boss pedal put between guitar and interface (Boss pedals all have 1MOhm buffers which are pretty good as it happens).
The additional buzzing compared to what you might get in stage is almost certainly down to being near a computer. Computers can emit all kinds of radio interference which single coil pickups are very susceptible to receiving. Add flourescent/low energy lighting, domestic lighting dimmers, switching power supplies, electrically noisy transformers in monitor amplifiers etc. into the equation and noise can quickly get out of hand.
A DI box won't reduce noise unless there's a ground-loop between two mains-powered pieces of kit when the earth-lift switch on the DI might make a difference.
The best answer to single coil noise is to first try having the guitar at different angles to the computer, monitor screen etc. and see if that helps, or to get the guitar further away from the sources of electrical noise. It might also be worth shielding the pickup and control cavities with copper foil or conductive paint connected to earth, though Fender have been applying conductive paint to the cavities in many of their instruments, even the less expensive Mexican ones, for some time. The usual give-away that this has been done at the factory is a wire screwed into the pickup or control cavity, or trem spring cavity on a Strat.
As for Teles and high gain, a Tele+fuzz->Marshall setup is as old as fuzzes and Marshalls. Or overdriven tweed Fender amps. You'll probably always get some noise, because a Tele bridge pickup in particular is quite a bit more powerful than the anaemic Strat vintage single coils, and a Tele Texas Special is about as powerful as a PAF humbucker and can really buzz away.
It's even quite possible the guitar is just as noisy on stage - it's just that playing live we and the audience tend to filter out the noise, it's only when recording or listening to a recording we spot it.