My computer is still making noise.  I don't know if it is the mouse or not but I don't think so.  It greatly increases when I open sonar or reaper.  I have my compute, my board, and my mackie blackbird onyx all plugged into a furman power conditioner.  the noise is a pulsing hum with crackling. It doesn't come through my mixdowns but it is just annoying as hell

I'd strip the machine down to the very basics (disconnect everything possible)... and see if the noise is still present.
I've seen a cheap USB cable cause similar "digital hash" type noise (connecting a Motif ES7 to a DAW).
 

Check your cabling to your monitors.  I noticed some weird sounds recently that I was hearing during computer operations.  Tracked it down to the monitors.  Couldn't hear it with headphones plugged directly into the audio interface.  If I unplugged the cables to the monitors, the noise definitely went away, so it wasn't coming directly from the computer.
 
I probably need to try some balanced 1/4" cables...

Jim Roseberry
I'd strip the machine down to the very basics (disconnect everything possible)... and see if the noise is still present.
I've seen a cheap USB cable cause similar "digital hash" type noise (connecting a Motif ES7 to a DAW).
 

do you mean the computer Jim? as in disconnect hard drives etc. or usb cables etc coming from it?
 

abacab
Check your cabling to your monitors.  I noticed some weird sounds recently that I was hearing during computer operations.  Tracked it down to the monitors.  Couldn't hear it with headphones plugged directly into the audio interface.  If I unplugged the cables to the monitors, the noise definitely went away, so it wasn't coming directly from the computer.
 
I probably need to try some balanced 1/4" cables...

I will try that
 

HighAndDry
 
do you mean the computer Jim? as in disconnect hard drives etc. or usb cables etc coming from it?

Disconnect all cables (peripherals) that aren't absolutely essential to the machine booting up.
Stripped to the very basics, does the noise persist?
If not, then you know it's one of the peripheral/cables.
I've seen a USB cable cause similar noise.  Swapped that out... and the noise was gone.
 

Having the DAW plugged into one outlet... and peripherals in another invites ground-loops (noise).
Using balanced cables where possible will minimize noise... (I'm sure you already know this)

There can be ground loops with both devices plugged into the same power outlet or strip.  I've seen it many times when I was doing guitar amp repair (in Nashville).  I just experienced it myself with a "Steel Guitar Black Box".  No matter where I plugged it in, same or separate power source, it caused ground loop hum (on different amps).  As good as the Black Box is ("audiophile" quality) it has the ground loop hum problem.  I had to use an AC power "ground lifter" with this device.

I've seen that too... (ground loop even when connected to the same outlet)
Using the same outlet certainly helps reduce the odds...
Using multiple outlets (in a typical home) will almost guarantee ground loop issues.
 

Ground loops suck.  The power in my studio can be a bit wonky, and I have stuff connected every which way from sideways.  Fighting 60Hz hum is a constant battle.  With my old setup, anytime I'd record guitar or base direct, I had to do it barefoot with one foot on the DI box.  Crazy.  I've made a lot of changes around here lately so I'm hoping it will be less of an issue now, but who knows.  Fortunately, there's always a workaround.  It just takes a little problem-solving.  Good luck!