I wanted to add my and experience to those who are thinking about trying Studio One. I had been using Sonar up to the X1 days and decided I wanted to see what other DAWs offered. I was also using Presonus FP10s and heard good things about Studio One, so I thought I would start there.
My work flow is mostly studio tracking/over dubs and mastering (and some MIDI), so YMMV if you are more into strictly MIDI. Presonus does have a product called Notion that integrates with Studio One, so if you work more with notation/MIDI, that is something I would look at (there is a Forum over at Presonus for that).
After working with Studio One for about a week, I found what I think is the hidden gem of Studio One - the Project page. The Project page is a built in mastering section where you can group your songs on a timeline and save them as a Project. From the Project page, you can jump back into the Song page and update/overdub, etc. a song or track. When you return to the Project page, you can use a single click to remaster the updated songs. As a small studio owner, you can jump from one customer's project to another in a matter of minutes and not have to hunt for folders and remember sequences. I know other programs provide this work flow, but it don't think it is as seamless as within Studio One (plus you need to purchase/maintain another program). You can also give a customer a mix down of all their songs from the Project page before they leave (again just a single click). There is not a lot of Youtubes on the Project page but there is some.
Another important note about Presonus is that Studio One is tightly integrated with Presonus hardware. Since Presonus produces both hardware and software, they control the drivers and make sure things talk. The FaderPort and CS units provide amazing control. I recently decided to replace my Berhinger BCF and BCR units with the newer StudioLive III mixer. The mixer allows you to jump from tracking mode to full DAW control with a single button push and will be a major improvement for my workflow. Note that for other control surfaces there is built in mapping capabilities within Studio One that work well (so you may be able to use your present control surface to control DAW parameters).
Hope this input helps someone here decide what is next for them.
Keep in mind, there are still great folks at both Cakewalk and Gibson and this looks to be a giant screwup of Gibson management at the top level. Reading through the forum these days, there are a bunch of really great people wondering what is next. I might suggest there is a great forum over at Presonus waiting to help if you decide to go in that direction.
Take care,
h