I agree the amp is important. There’s a Premier Guitar rig rundown of one of his setups on youtube.
Any humbucker equipped guitar with vintage rather than hot output into a Boogie combo with the mids boosted rather than massively cut or a Dumble ODS, again with plenty of mids should get into the right sort of area. Failing that maybe a Fender combo and a smooth and sustaining kind of fuzz, maybe a Big Muff with the amp mids boosted to counter the Muff’s mid cut for the lead sound.
It might be an idea to add a compressor to compensate for not being able to get a guitar-amp-speaker-guitar sustaining feedback loop going. From what I’ve heard about his rigs he’s not a quiet guitarist.