Thanks for the responses. Forgot to mention "Win 7". Drivers are the latest from MOTU. I suspect it is operator error on my part, or just ignorance.
After some re-evaluation of my plans I have decided to leave the MOTU with my older PC in a rehearsal studio where I actually need the I/O capacity and just buy a new, smaller interface for my new PC. Any suggestions on a 4in/2- or 4-out model that is compatible with Platinum?
I'm sure I will be back with more questions, as I will be doing things I have not done in the past, particularly using virtual instruments.
Thanks for the help.