If you're looking for the lowest possible round-trip latency with a USB audio interface, you need to look at MOTU or RME.
- The MOTU AVB series yields 4.9ms total round-trip latency at a 64-samples ASIO buffer size/44.1k
- The RME UBS units yield 4.3ms total round-trip latency at a 48-sample ASIO buffer size/44.1k
At those buffer sizes, that's on-par with PCIe units.
As long as your machine can keep up with the load, performance will be glitch-free.
The best PCIe audio interfaces let you take the ASIO buffer size down to 32 or even 16-samples.
That's sub 3ms total round-trip latency.
If lowest possible round-trip latency is paramount to your workflow, don't skimp on the audio interface.
In this scenario, lesser units won't do.
Go with a proven rock-solid performer... and you'll never give the audio interface a second thought.
Aside from the PC itself, the audio interface is the second most critical choice in a rock-solid DAW.