Hi everyone, thanks for the recommendations.  I have already disabled power management for all USB hubs.  Also I have all antivirus and even with internet disabled, it still happened.
 
I then tried the Scarlett Solo audio interface, which seemed to have solved the issue except that I can't work with such a "humble" device. 
 
I then purchased a brand new MOTU 828es.  Seems to have solved that issue,
 
However, now I get crashes.  Not the kind that produce dump files, these are "program not responding" crashes in which I have to close CW manually, restart comp.  It happens about once an hour, more with larger projects...but otherwise very solid.  I have tried to use USB2, and that hasn't had any effect.  I have tried the WASPI drivers and then I get pops/cracks.  I'm stumped and it's hurting my business right now.  
 
Could it be an issue with my motherboard, maybe bad usb headers?