Start with a monitor mix with correction mode on, first, get it where you have a nice balance when you turn ARC 2 off and on, play with the speaker emulations until you get a good average mix in all modes, then turn it off and check the mix on headphones last. When you get a mix that sounds good in all (or most) of the various modes, you'll be there. When I first got ARC 2, I was dubious that any mix could sound good in all modes until I played Steely Dan over the system. Sure enough, their mix sound great in any mode I put it through, though there are big differences going from "flat" to "small TV". I soon learned to compensate, and my mixes started sounding better. It took me a while to learn the system, but now, I get to the finish line much faster, and it was worth the effort.
I also use Mixchecker for their emulations, too. A good combination with ARC 2,