I tried Win 10 upgrade in place on Win 8.1 DAW. In the past I alway did a clean install. I thought I would try in place and if it did not work, I would just bite the bullet and do a clean install. All my programs were still there and work flawlessly. I had to re-register AD and Melodyne since it was essentially a new machine, but that was it.
Do not do it from Windows update. Download the upgrade and make a USB stick or DVD so you have a permanent copy.