Well I can't say enough good things about amp Sims. Bought Line 6 Gear Box Gold about Five years ago and really leaned fast how quick and easy it was to start a song, grab a sound, get a trk down and go back and play with it using different patches that I had never thought of, layering them.......and on and on!
So for about three years, I didn't use my amps. In fact I got really fond of playing through the amp Sims into my monitor (especially Head Case). I just love the response I get from those monitors.
About six months ago I started playing through tubes again. Wow, I realized what I missed.
Then as an off hand trail, I stuck my 4040 in front of the speaker cab and recorded a take. It was very different than the takes I made with the Sims. It sounded great with hardly any effort!!
Not to make this into a " real vs itb " post, I'm just saying both are really good. And both have their weaknesses.
Given the choice, I may go with the.......π