Geez, this sounds like the exact problem they had with the 1818VSL which is now defunct.  You would think PreSonus would be more diligent about their compatibility testing.
 
PreSonus makes some great affordable hardware, but their software/driver support sucks.  I'm not sure if they outsource their driver coding, but most of their software dollars are going into Studio One development and not in to their own products.
 
The sad thing is, they've made some great interfaces, but their lack of driver support makes them useless to customers.  People are going to upgrade their computers and OS'es, if PS can't keep up with compatibility and software sustaining, they need to get out of the hardware business.

This interface seems to be having some growing pains, which is common for a new product but I agree with you denverdrummer one would think Presonus learned their lesson after the VSL fiasco we all remember. There is a huge thread over on the GS board regarding horrible latency. An interface without solid drivers is going to be nothing but problematic no matter how innovative it is. You can have the greatest pre-amps and converters but if the unit keeps crashing or has poor performance it becomes a huge headache.
 
I think the problem lies with companies farming out the driver development to 3rd party firms like DICE or TheSycon instead of keeping it in house like I believe RME does. They lose control and end up with a generic driver that may work but isn't as optimized for the specific hardware as it could be  It's just a thought.

Thanks evryone for your help and views on this interface,  I will talk to there tech support on monday and if no resovle I will return it.
 

Presonus Just released beta drivers for studio 192 for windows 10 and it seems to be runnig very well so far.