Hi, and welcome to this forum. Are you using simple instrument track, or separate audio and MIDI tracks? Are you having trouble with all softsynths? If so, maybe go through the videos at
http://www.cakewalk.com/CakeTV/SONAR-University/Get-Started . You will need an audio track to get the sound out of the instrument, and a MIDI track to trigger it (or Simple Instrument track, which is both audio and MIDI in one). If you have more questions, just ask again

Best of luck.