Personally, I only download software from the vendors website. If you have downloaded Melodyne directly from
http://celemony.com/ and AVG is saying it's a threat, then this would be a false positive. If, after updating AVG's definitions and it still flags Melodyne as a threat, you should contact AVG about this to let them know.
If Melodyne was actually infected with a real threat, then I am sure this forum would be lit up like a Christmas tree with people complaining.