You know Bob I have WAY too much gear.
I was reading a post by Danny Danzi the other day and it sounds like he has "sworn off"
(hope I'm not putting words in your mouth Danny, my apologies if I misunderstood) outboard gear.
Sometimes I think I'd be time (and money) ahead to focus on getting a good "clean" recording,
instead of "playing" with all the toys.
Sometimes (always) too many options burn way too much time and the muse moves on.
You've got 2 good pres in the Focusrite.
The 610's do grow some "hair", quickly, when pushed, gotta watch that.
Can't speak to the ISA-One.
You might look at a 500 series box (another one of my "toys"), lots of preamp options with that.
Keeps the desk clean, everything organized in one spot, and by sharing the power supply you
save a little dough on each pre.
Just my nickel 98.
All the best,
Tom
Oh and to GS, I've looked at the circle audio, I was "tempted", went with the 500 option.