It sounds to me like your audio interface was hit by a power surge. Do you have it plugged into a UPS?
I used to use surge protectors until I lived in a small town where frequent lightning storms and power outages taught me to use a UPS. Damage to gear is random, too. Sometimes things will still work, but do odd things from time to time... like what's happening with you.
I'd try a few things:
- another USB port,
- another AI,
- another computer (with your AI).