Thanks for feedback,
I have had it set to 500, Ill try going to 1000, and see what results I get, I had thought going to 1 second would be somewhat excessive and possibly cause other issues (and relatively like a long time, LOL.), albeit I usually run RME-UFX at high or highest latency setting for playback/editing, Which would lead to a question,
Is their any reason not to run an audio interface at the highest latency, for playback/editing?
I determined a problem/solution (for this project at least)
I had spent some time to late last night doing some sleuthing (which I detest) track by track, with a such troubled project, only 3 soft synth tracks (all dropping random notes) and 20 analog tracks, and found on "1" of 10 audio vocal tracks,
IZOTOPE Breath control running in ProChannel FX-Chain module, as it turns out this was the culprit, and like a switch, "on" midi notes are dropped, "remove" all midi notes are all OK, and perfectly repeatable. This led me to recall issues in the past whenever using IZOTOPE Nectar plugin in an FX bin, they really seem to excessively hog processing time to the max. Normally now when using their plugins, I set them up on a track as desired, create a pre-set and then run as a process fx on track or clip, and then get rid of them, as far as possible, (perhaps to even store them on a different computer, behind a glass enclosure with a hammer, with nuclear symbol labeled "use only in case of extreme emergencies", LOL, but they do their job well if given their space). Ill try it though bumping up midi playback buffer time, and see if it works in "real time", without affecting midi synths.
Also the IZOTOPE Nectar fx have a number of option settings for sync, buffer and delay compensation which I'm not sure I fully understand yet, but do refer specifically to Sonar compatibility settings, dam more homework to do, :(.
Cheers