Only been on W10 for a few days, but so far the experience has been flawless. I did this at the same time as updating my soundcard to an RME one which gave me some problems (related to the USB port rather than the OS). There's a few changes to the UI which will take a bit of learning, but otherwise I'm happy.
Some older hardware may not install due to the enhanced driver signing - but again there are workarounds to this if you need them. There's also the general worry about it sending all your activity to MS - you can turn off items that it advertises of course, but it might still track stuff covertly. Doesn't worry me tbh.
<EDIT> I'm running a bunch of VST/VSTi including Omnisphere, AAS, Kontakt, Arturia, EZD. Also Waves Gold pack and the Waves SSL 4000. All working good.