I did a clean install of Windows 10. By this I mean I formatted the OS Drive and installed from scratch. Nothing left of Windows 8.1 at all.
Then I went and downloaded the latest drivers from RME which say they are Windows 10 compliant.
It does 'work' but hitting stop during playback causes a pop. Doing anything really. I'm not sure what the problem is. I'm considering borrowing one of these Firewire cables and re-testing with that to see if my issue goes away.
Noel? You're on Windows 10. How's your UFX working?