I use a Mackie Control and 2 extenders for 24 tracks on the desk.
Perfect automation... no issues at all.
I also use a <
Presonus Central Station> as the interface between the DAC and three sets of monitors for easy switching between A, B, & C speakers. Also provides a handy foot-switch controlled talkback feature with a built-in condenser mic.
Since I control my speaker volume in the analog world with Central Station, that leaves the Master Fader on the Mackie Control Surface for something more useful...
like the audio metronome in S4! I simply have the Mackie Control master bus assigned to bus 1 and that bus is identified in the S4 audio metronome properties tab as the output for the analog metronome signal. Works beautifully. I simply leave the click enabled on record and playback all the time for gapless click track control. When I want to hear it, change it's volume, or nix it altogether, it's always right there next to my right hand on the transport.
I just love it when stuff works!