Try WDM driver and see if that helps.
Are you using higher sample rate like 96K ?
If so, try 48K or 44.1K.
Also, small buffer sizes only matter when recording(for low latency)
For mixing/playback, have you tried a really large one 1024/2048 ?
If installed, uninstall ASIO4ALL.
If your video card has audio drivers, disable them.
Disable the internal sound card in your PC.
If you have a WIFI, disable it.
Temporarily disable antivirus.
These are all pretty standard things to try.