Quick update to this one just to better close out where I went with this (GNX3000 unit).
Drivers - The "ASIO" drivers that came with this appear to be similar to ASIO4ALL. WDM is actually faster, and programs came up with "GNX3000 not connected" when starting them. Latency is a "no go" in 95% of the cases, and since this "ASIO" driver is intrusive I uninstalled the driver set. As an "audio interface" this is not a recommended option.
X-Edit 2 - The GUI to "program the guts" works without the drivers (thank God), and is pretty indispensable for initial setup. As I intend to use this as DI/Solid State stomp box, I focused on setting up the first 5 user presets to be "normalized" on all amp channels (the channel switch has options for up to 1, 2, warped (mixed) and for all 5 presets I chose all to have 15 variations available). Setup for this takes a while, but when completed, the USB umbilical can be unplugged. Additionally, within X-Edit 2 there are options to simulate Humbucker->Single Coil and vice versa, as well as "simulating an amp performance through regular speakers." Nice features, but a
huge con to these is that I have yet to find how to program into the stomp box potion (along with reverb which also seems "baked"). Another con is that the FX are set by preset, not channel, so all 3 channels of the same preset have the same FX in them - more of a nuisance as HB->SC is a nicety that would be better with a quick on/off.
Connections - As my main use for this ATM is straight into my Saffire, I choose a headphone->L/R TS connection (Y-split) cable. As many patches internally generate stereo, this seemed the easiest way to capture both (and the volume knob on the unit is handy). For amp use, can simply run the mono amp output to a clean amp channel.
Thus far, the expression Pedal has yet to be (custom) programmed for anything, but will take up to 3 FX so want to think about how I would employ this going forward. Wah-Wah (enabled/disabled by pressure on the toe switch) and/or volume are programmed into many presets by default.