Ok, it's a weird one. It refused to work, even after rebooting the PC twice.
I decided to pull the USB cord out from the Saffire 6, and then plugged in back in again and it has now all come to life. So, power-cycling the Saffire 6 seems to have done the trick for whatever reason.
I'm just getting back into DAW/DTM after not doing anything for over a decade, so I'm not a complete newbie, I started out using several Atari1040STE, then PCs using ****base for years (I loathed the dongle!), ACID, Fruity Loops etc.
Thanks for your help, much appreciated.