I use 2 Studio-Captures synched together for 32 ins and 20 outs. When used in this configuration you can only use 44.1 sample rate! If you want any higher you can only use 1 at a time in ASIO. Also, the reverb in this thing is horrible!!!!! I have had clients when working, the few times I tried using it, actually ask me to turn it off!!
Those are the main downside points with the Studio-Captures from my experience. I am still very, very happy with these interfaces and feel that they are worth every penny I paid for them. They are used every day and have not had 1 crash caused by them. Any time there has been a crash has been from me mucking around with other features or plugins, experimenting in SPLAT.
Btw, I have not tried any other drivers than ASIO. With ASIO I can get some pretty big projects playing as low as 96 samples! 128 samples covers anything else pretty well.