I have a US-16x08, and am current with Win10 updates. I've had no issue with its driver.
I know that doesn't help, but I'm wondering what the Events tab in the Device Manager entry for the US-2x2 shows.
Note that some major Win10 updates, like 1511, will reset some Preferences back to Microsoft's preferred defaults. I'd do a bit more research before I'd suggest rolling back.
Things like the Realtek HD audio driver can get reenabled, for example.
I've been dealing with a wicked little issue...my AMD display driver crashing and recovering several times per day. I
think I have that bad boy resolved. When I disabled and then uninstalled the Realtek driver, it left a nasty bit behind. Yesterday, I discovered a Service called something like Realtek Loader trying to start...and failing...and failing (no driver!). So I got rid of that service. Haven't had a display driver crash since.
Knock wood.