Yes - it can. The last exceptions I saw are Studio Indstruments & TH3 for Cakewalk that are installed on C:
Rest seems customizable - and I hope soon all components without exception.
The trick is they use a "Cakewalk Core" directory for program code - very clever designed. So I placed it beside my Splat Directory. No Problems yet.
The programmers are really working hard - respect.
Sorry for my "German" English :-)