Not using TB here...
 
Running Win10x64 Pro with the latest Win10 updates.
All is working well (including iLok protected plugins).

Billy, I'm sure you've tried this... but have you uninstalled/reinstalled the TB drivers for the motherboard?
 
With some audio and MIDI hardware, installing the driver using Win7 or Win8 compatibility mode worked.
ie:  Prior to a proper Win10 driver, this worked for Machine Studio and Komplete Kontrol.

My Win 10 Pro was upgraded to the 1511 version yesterday.  My Roland Studio-Capture was detected as a new device and installed.  No other issues that I know of.  Sonar Platinum and all plug-ins run OK.  No problem with iLok, etc.
   

I've just applied the Windows 10 "Fall Update".
 
Addictive Drums 2 thinks my computer has changed to the point where it says that "There is an authorization problem" and "please run the installer"
 
(My project played back OK, but I'm not confident that will be the case for much longer, without some kind of intervention.)
 
When I run the XLN Online Installer, it says "You currently have your maximum amount of active computers. Remove old unused computers if you need to register a new computer."
 
Both "slots" - apparently you can register two computers - are the same physical machine. I think I used up the second slot when I re-installed AD after I upgraded to Windows 10 from Win 7, a few months ago.
 
One of them is labelled "Windows 10 64-bit", the other is "Other/don't know".
I'm going to try "removing" the computer in the second slot, and see if AD magically becomes authorized on this computer. 
 
UPDATE:
The XLN Installer allowed me to re-register the PC, then asked to update the Installer app itself, then said 1 item needed updating: "XLN Cloud Sync". I don't know or care what that is, but it only took a few minutes.
 
My project now opens without warning messages.
 

Dropouts.

Same as stickman393, but for Addictive Keys.

Also :
* iTunes hosed, can no longer sync (error 54 - permissions or summat)
* certain devices re-installed
* W Explorer needed to passes/reboots to index everything
* took 12 hours to download (i live in a village far from the madding crowd)
* networking seems to be very sluggish - internet speeds way down

And thats starters for 10.

Not a particularly happy camper so far.

Cheers.
Jerry

New W10 issue:  When playing a project, screen no longer scrolls. Must scroll manually.  

Anonymungus!
New W10 issue:  When playing a project, screen no longer scrolls. Must scroll manually.  

Check your keyboard to make sure that the "scroll lock" is not turned on. This can cause what you are seeing.

John
I have been on Win 10 from the beginning. No problems with it at all.  

Good to know!  I might ask to borrow your system some day :)
 
-D

joakes
Same as stickman393, but for Addictive Keys.

Also :
* iTunes hosed, can no longer sync (error 54 - permissions or summat)
* certain devices re-installed
* W Explorer needed to passes/reboots to index everything
* took 12 hours to download (i live in a village far from the madding crowd)
* networking seems to be very sluggish - internet speeds way down

And thats starters for 10.

Not a particularly happy camper so far.

Cheers.
Jerry

None of this looks like bugs. Areas of the OS are getting reset (probably for a good reason) and cache is obviously been reset. It should speed up after a few days..

Anyway glad I have windows update set to defer. Much more interesting to read it than experience it. Also very glad I'm still not using it for my DAW.