I bought Reason 2 probably ten years ago, and using it as a spare "synth rack" within SONAR via ReWire was all I ever did with it (hated the sequencer). As far as I can remember, stability was great and the features worked like they should. A bit of a hassle having to run two different apps and load/save two different session files though.
I've since found VST alternatives to all my favorite Reason synths/patches, so I don't even keep it installed anymore.
Sven