If you need low round trip latency for monitoring through a DAW then RME do the business. Their driver and firmware support and installation (different firmware depending whether you're using Mac or PC) to date is amongst the best, if not the best. It works fine off USB2, USB3, Firewire 400 and connected to Thunderbolt 2 via a firewire adaptor cable.
I've used my UFX for field recording at a friend's house armed with the UFX, a 32GB USB stick and an iPad to run RME's iOS version of totalmix. Very straightforward to do.
As for audio quality, the fact is that the mid-price interfaces from Roland, Focusrite, almost anyone, nowadays are all pretty good. Particular AD/DA chips are often used by several manufacturers in products in different price brackets. For example the UFX uses the same DA chip as a less expensive Presonus interface. The difference with the "higher end" tends to be in the drivers and the analogue components, power filtering etc. Also microphone pres and background noise levels come into it.
There's a law of diminishing returns with interfaces like there is with anything else, so once you get beyond a certain point you have to spend quite a bit more to get increasingly less noticable improvement in audio quality. Quite where that point is is debatable of course. I wouldn't get too hung up over 3dB difference in dynamic range though, at least not when you're looking at ranges of over 110-115dB. In the real world that's not very relevant.
If it helps the RME mic pres are quieter than my Focusrite octopre pres, and I think they sound a little fuller, but it's not the kind of difference that makes you sit up and take notice.
I went with RME primarily for the number of inputs and the very low latency drivers. I also considered MOTU but at the time RME struck me as the better option for me. It helped that RME were quick at answering a couple of questions I had and at the time there were some doubts about MOTU's USB performance compared to firewire and I didn't want to have to mess around with firewire on a Windows 8+ PC.
I have a MOTU microlite MIDI interface that works so well I can forget it even exists, which is more than I can say for M-Audio :-/
Both RME and MOTU are reputable, well established and highly regarded and in the music/audio business that says something. In car terms deciding between them (and Apogee if you're Mac only) is a bit like deciding between buying a new Ford Mustang and a Jaguar. The basics are solid in both so it comes down to the little differences and what matters to one person might not matter so much to another.