Funny thing is Propellerheads said it would never ever happen.
Reason was one of my first programs before I used before [cough]Cubase[/cough] and Sonar. Which was a great way to learn about routing hardware even if it is indeed virtual.
I know the sequencer has improved since I used it however it's one of programs which in the past had it's internal limitations unless you just used it as a Rewire Slave. Which with some DAW caused extra latency issues. Sonar does have it's complications however it can be easy or hard as you want it to be.