If you click the [Multi-Monitor] button, Direct Mixer A–D will be output directly to output jacks 1–8.
OUTPUT 1-2 & OUTPUT 9-10 ~~~> Direct Mixer A
OUTPUT 3-4 ~~~> Direct Mixer B
OUTPUT 5-6 ~~~> Direct Mixer C
OUTPUT 7-8 ~~~> Direct Mixer D
Click Close
On the Patch Bay, Select:OUTPUT 1-2 ~~~> Direct Mix A
OUTPUT 3-4 ~~~> Wave OUT 3-4
OUTPUT 5-6 ~~~> Wave OUT 5-6
OUTPUT 7-8 ~~~> Wave OUT 7-8
OUTPUT 9-10 ~~~> Wave OUT 9-10
Basically you have to set the Direct Mix to use Mixer B to send the audio alt 3/4, so you will follow the settings above and when you are ready to listen to the music through the speakers connected to Outs 3/4, Press the Mix Select Button until you see Mix B and this will send the audio to those monitors connected to 3/4.
The easiest way is to get a Mackie Big Knob. This is what I use to A/B/C my mixes $299.00 but you can find them for about $239.00
Mackie Big Knob ~~~> Studio Control Centers
The Behringer
XENYX CONTROL 1USB Studio Control is a good buy with three Monitor select choices as well, for a lot less $$$.