Here is a video which details causes of realtime audio problems.
If you do not fully understand latency, audio buffer size settings, and so on or
your new system with a killer CPU still has audio issues, check this out.
Contains some graphic animations illustrating the above.
https://www.youtube.com/watch?v=GUsLLEkswzE&feature=player_embedded
Examples use Cubase but the principles apply to every DAW.
 
Thanks to chimpspanner in the Cubase forum for this link.

Thank you SOOOO much for providing such a video, as this issue comes up fairly often, and IS something that can and does happen no matter what DAW you are using.
 
Bob Bone
 

Sure Bob,
Although basic, it ties things together nicely.
 
Michael